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[1] 鏉庡媷锛庤偨涓村簥钀ュ吇瀛M]锛庡寳浜細鍖椾含澶у鍖诲鍑虹増绀撅紝2012.
[2] 鍐鐕曪紝璁℃垚锛庡鑲藉湪铔嬬櫧璐ㄨ惀鍏讳腑鐨勪綔鐢╗j]锛庡姩鐗╄惀鍏诲鎶ワ紝2001锛?3(3)锛?-13.
[3] Agar WT锛孒ird F J锛孲idhu G S. The active absoption of amino-acids by the intestine[J]锛嶱hysiol.锛?953锛?21(2)锛?55涓€263.
[4] Neway H锛孲mith P H . Intercellular hydrolysis of dipeptides during intestinal absorption[J]锛嶱hysiol.锛?996锛?52锛?67涓€380.
[5] Daniel H. Molecular and Integrative PhysioI0gy of Intestinal Peptide Transport[J]锛嶢nnual Rev. Physiol.锛?004锛?6锛?61涓€384.
[6] zaloga G P . Physiologic effects of peptides based enternal formulae[J]锛嶯utrition in cIinical practice锛?990锛?锛?31鈥?37.
[7] Hara H锛孎unabili M锛孖wata锛宔t al . Portal absorption of small peptides in rats under unrestrained conditions[J]锛嶫 Nutr.锛?984锛?14锛?122鈥?129.
[8] Leonard J V锛孧arrs T C锛孉ddison J M锛宔t al. Intestinal absorption of amino acids and peptides in Hartnup disorder[J]锛嶱ediatr Res.锛?976锛?0锛?锛?246鈥?49
[9] 鏉庡啝妤狅紝澶忛洩濞燂紝闅嗚€€鑸紝绛?鎶楄弻鑲界殑鐮旂┒杩涘睍鍙婂叾搴旂敤[J]锛庡姩鐗╄惀鍏诲鎶ワ紝2014锛?6(1)锛?7涓€25.
[10] 鐜嬫槬鑹筹紝鐢伴噾寮猴紝鐜嬪己.鏀瑰杽蹇冭绠″仴搴风殑椋熸簮鎬х敓鐗╂椿鎬ц偨鏋勬晥鍏崇郴鐮旂┒杩涘睍[J]锛庨鍝佺瀛︼紝2010锛?1(13)锛?07涓€311.
[11] 鏉庝笘鏁忥紟椋熸簮鎬ф椿鎬у鑲戒笌闄嶈鍘嬬爺绌惰繘灞曟棩[J]锛庤€佸勾鍖诲淇濆仴锛?008锛?4(2)锛?25涓€127.
[12] Dziuba J锛孧inkiewicz P锛孨alecz D锛宔t al. Database of biologically active peptide sequences[J]锛嶯attrunges.锛?999锛?3锛?90鈥?95.鈥?/p>
[13] Shin Z锛孻u R锛孭ark S A锛宔t al. His-His-Leu 锛宎n angiotensin 1 converting enzyme inhibitory peptide derived from Korean soybean paste锛宔xerts arltihyPertensive activity in vivo[J]锛嶫 Agric Food chem.锛?001锛?9(6)锛?004涓€3009.
[14] Hirasawa M , Shijubo N锛孶ede T锛宔t al. Integhn expression and ability to adhere to extracellular matrix protelns and endothelial cells in human lung cancer lines[J]锛嶣r J Cancer.锛?994锛?0(3)锛?66鈥?73.
[15] Florentin l锛孋hung V锛孧artinez J锛宔t al. In vivo immuno-pharmacological properties of tuftsin(Thr-Lys-Pro-Arg)and some analogues[J]锛嶮ethods Find Exp Clin Pharmacol.锛?986锛?(2)锛?3鈥?0.
[16] Tsuchita H锛孲uzuki T锛孠uwata T.The effect of casein phosphopeptides on calcium absorption from calcium-fortified milk in growing rats[J]锛嶣r J Nutr.锛?001锛?5(1)锛?涓€10.
[17] 寮犳槉锛屼换鍙戞斂锛庡ぉ鐒舵姉姘у寲鑲界殑鐮旂┒杩涘睍[J]锛庨鍝佺瀛︼紝2008锛?9(4)锛?43涓€447.
[18] 寮犺帀鑾夛紝涓ョ兢鑺筹紝鐜嬫伂锛庡ぇ璞嗙敓鐗╂椿鎬ц偨鐨勫垎绂诲強鍏舵姉姘у寲娲绘€х爺绌禰J]锛庨鍝佺瀛︼紝2007锛?8(5)锛?08涓€211.
[19] 鑽ｅ缓鍗庯紝鏉庡皬瀹氾紝璋㈢瑪閽э紟澶ц眴鑲戒綋澶栨姉姘у寲鏁堟灉鐨勭爺绌禰J]锛庨鍝佺瀛︼紝2002锛?3(11)锛?18涓€120.
[20] 宕斿墤锛屾潕鍏嗛檱锛屾椽鍟歌幒鍚燂紟鑷敱鍩虹敓鐗╂姉姘у寲涓庣柧鐥匸J]锛庢竻鍗庡ぇ瀛﹀鎶ヨ嚜鐒剁瀛︾増锛?000锛?0(6)锛?涓€2.
[21] 闄嗚瀺锛岀帇鍗擄紟灏忓垎瀛愬鑲芥姉鑲跨槫浣滅敤鐨勭爺绌惰繘灞昜J]锛庡ぉ娲ュ尰绉戝ぇ瀛﹀鎶ワ紝2005锛?1(3)锛?99涓€502.
[22] Ch猫ne P锛孎uchs J锛孊ohn J锛宔t al. A small synthetic peptide , which inhibits the p53-hdm2 interaction锛宻timulates the p53 pathway in tumour cell lines[J]锛嶫 Mol Biol.锛?000锛?99锛?)锛?45涓€253.
[23] Issaeva N锛孎riedler A锛孊ozko P锛宔t al. Rescue of mutants of the tumor supPressor p53 in cancer cells by a designed peptide[J]锛嶱roc Natl Acad Sci USA.锛?003锛?00(23)锛?3303涓€13307.
[24] 鏈辩淮閾?涓村簥钀ュ吇瑙掕壊鐨勮浆鍙橈細浠庤惀鍏绘敮鎸佸埌瑙ｆ€＄枟[J]锛庤偁澶栦笌鑲犲唴钀ュ吇锛?009锛?6(1锛夛細1鈥?l.
[25] 瑁存柊鑽ｏ紝鏉ㄥ鎮︼紝寮犲彫閿嬶紝绛?娴锋磱鑳跺師鑲芥姉鐨偆鑰佸寲浣滅敤鐨勫疄楠岀爺绌禰J]锛庝腑鍗庨闃插尰瀛︽潅蹇楋紝2008锛?2(4)锛?35鈥?38.
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