荨麻疹能吃氨基酸吗(你对化学试剂过敏吗？)

浣犲鍖栧璇曞墏杩囨晱鍚楄嫳璇?/strong>

鏈枃鏉ヨ嚜寰俊鍏紬鍙凤細X-MOLNews

鍚勪綅鍚屼粊锛屾偍鎯宠繃鑷繁鐨勭毊鑲や笉閫傚拰鑷繁鐢ㄧ殑璇曞墏鏈夊叧鍚楋紵

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涓嶅悓鍖栧鐗╄川鐨勭毊鑲ゆ晱鎰熸€ц瘯楠岋紙缁勮兒浣滀负闃虫€у鐓э級銆傚浘鐗囨潵婧愶細J. Org. Chem.[1]

浠庡浘鐗囧彲浠ユ竻鏅板湴鐪嬪埌HATU銆丠BTU鍜孒CTU涓夌甯歌缂╁悎鍓傚紩璧峰彈璇曡€呭ぇ闈㈢Н杩囨晱鎬ц崹楹荤柟锛孎moc淇濇姢鐨勬皑鍩洪吀鍜孌CC寮曡捣鐨勮崹楹荤柟瑕佸皬浜庨槼鎬у鐓х粍鑳恒€傞櫎DCC澶栵紝鍏朵綑璇曞墏鍧囦负鍙楄瘯鑰呭伐浣滀腑鏈夎繃闀挎湡鎺ヨЕ鐨勮瘯鍓傘€侶ATU銆丠BTU鍜孌CC宸茬粡琚姤閬撳彲寮曡捣浜鸿繃鏁忓弽搴旓紝浣嗚鍙楄瘯鑰呮鍓嶄粠鏈帴瑙﹁繃DCC锛岃繖涔熻兘瑙ｉ噴涓轰粈涔圖CC寮曡捣鐨勮繃鏁忕幇璞¤繙涓嶅強鍏朵粬涓変釜缂╁悎鍓傘€傝繖浣嶅彈璇曡€呯殑妗堜緥鍛婅瘔澶уHCTU浜﹀彲寮曡捣浜鸿繃鏁忓弽搴斻€傝鍙楄瘯鑰呭悕鍙獽ate J. McKnelly锛屽湪鍔犲埄绂忓凹浜氬ぇ瀛﹀皵婀惧垎鏍★紙University of California, Irvine锛変粠浜嬪鑲藉悎鎴愬伐浣滄椂鍙戠幇浜嗚嚜宸辩殑杩囨晱鐥囩姸鍜岀缉鍚堝墏鏈夊叧锛屽苟灏嗗叾缁忓巻鎾板啓鎴愭枃鍙戣〃鍦ㄦ湁鏈哄寲瀛︾煡鍚嶆湡鍒?strong>J. Org. Chem.[1]銆?/p>

涓夌鑲界缉鍚堝墏銆傚浘鐗囨潵婧愶細J. Org. Chem. [1]

Kate J. McKnelly鎻忚堪锛屽ス浜?015骞?鏈堝紑濮嬩粠浜嬪鑲藉悎鎴愶紝鍦?016骞?鏈堝彂鐜拌嚜宸卞嚭鐜板挸鍡姐€佹祦榧绘稌銆佹墦鍠峰殢绛夌棁鐘讹紝澶ф涓€骞翠互鍚庡ス鐨勭棁鐘跺彂灞曞埌浜嗚繃鏁忓弽搴旂骇鍒€傚湪鍖诲笀鐨勫府鍔╀笅锛屽ス鎵惧埌浜嗚繃鏁忔簮锛屽氨鏄ス鏃ュ父宸ヤ綔楂橀娆℃帴瑙︾殑澶氳偨缂╁悎鍓傘€俒2] 鐪嬪埌杩欙紝鏈夊灏戠敤杩囩缉鍚堝墏鐨勫悓瀛﹀紑濮嬫€€鐤戣嚜宸辨煇浜涚棁鐘剁殑鍘熷洜浜嗐€?/p>

Kate J. McKnelly銆傚浘鐗囨潵婧愶細Nowick research group [3]

瀛︿範杩囩敓鐗╁尰鑽浉鍏崇煡璇嗙殑鏈嬪弸浼拌瀵瑰厤鐤師鎬ф湁鎵€浜嗚В銆備竴鑸潵璇达紝澶у垎瀛愮墿璐ㄥ瓨鍦ㄥ厤鐤師鎬х殑鍙兘鎬ц緝澶э紝鍙兘浼氬紩璧锋満浣撶殑鍚勭杩囨晱鍙嶅簲銆傚皬鍒嗗瓙鍖栧悎鐗╃殑鍒嗗瓙閲忓皬閫氬父涓嶄細琚厤鐤郴缁熺洿鎺ヨ瘑鍒紝寮曡捣杩囨晱鍙嶅簲鐨勫彲鑳芥€ч€氬父杈冨皬銆傚彲鍑′簨鏃犵粷瀵癸紝纭疄鏈変竴浜涘寲鍚堢墿琚姤閬撲簡鍙紩璧疯繃鏁忓弽搴斻€傝繖鏄粈涔堝師鍥狅紵鑻卞浗鍒╁吂澶у鍖栧鐢熺墿瀛︽暀鎺圧obin Bon璁や负锛屽皬鍒嗗瓙铏界劧涓嶄細琚厤鐤郴缁熺洿鎺ヨ瘑鍒紝浣嗘槸鍏朵竴鏃﹀拰鏌愪簺铔嬬櫧缁撳悎鍚庡彲寮曡捣璇ヨ泲鐧界粨鏋勫彂鐢熸敼鍙樸€傝泲鐧界粏寰殑缁撴瀯鏀瑰彉瀵艰嚧鍏嶇柅绯荤粺灏嗗叾璇嗗埆鎴愬鏉ョ墿璐ㄨ€屼骇鐢熸姉浣撹繘鑰屽紩鍙戣繃鏁忓弽搴斻€傚凡鐭ョ殑鑳藉紩璧疯繃鏁忕殑鐗╄川闄や簡涓婇潰浠嬬粛鐨勭缉鍚堝墏锛岃繕鏈変竴浜涙煋鏂欍€侀噾灞炵墿璐ㄦ瘮濡傞晬绫汇€佸尰鑽腑闂翠綋鎴栬嵂鍝佹瘮濡傛姉鐢熺礌绛夌瓑銆?/p>

杩欎笘鐣屼笂鐨勫寲鍚堢墿浣曟鍗冧竾锛屽彲鎴戜滑瀵硅繖鏂归潰鐨勪俊鎭嵈鐭ヤ箣鐢氬皯銆傚浣曞湪宸ヤ綔涓閬胯繖绫婚闄╁挨涓洪噸瑕併€侹ate J. McKnelly涔熸彁鍒帮紝濂瑰湪鍒╁吂澶уAndrew Wilson瀹為獙瀹ゆ敾璇荤澹浣嶆湡闂达紝灏辨病鏈夊嚭鐜拌繃鏁忓弽搴斻€傝繖鏄洜涓篈ndrew Wilson鏄庣‘瑕佹眰涓ョ鏄撹繃鏁忚€呮搷浣淗ATU鍜孒BTU銆傚叾瀹為獙瀹ゆ槑纭垪鍑轰簡涓€浜涘紩璧疯繃鏁忓弽搴旂殑璇曞墏锛岀爺绌朵汉鍛樺湪浣跨敤杩欎簺璇曞墏鏃惰瀵嗗垏鍏虫敞鑷韩鍋ュ悍銆傚湪鐪嬪埌Kate J. McKnelly瀵笻CTU杩囨晱鐨勬姤閬撳悗锛孉ndrew Wilson鍙堟洿鏂颁簡閭ｄ簺鏄撹繃鏁忚瘯鍓傛竻鍗曘€傚彲瑙侊紝瀹屽杽鐨勫埗搴︽槸闄嶄綆浜嬫晠鎶靛尽椋庨櫓鐨勬湁鏁堟墜娈点€?/p>

Kate J. McKnelly鍦ㄥ叾鏂囩珷涓篃鎬荤粨浜嗕竴濂楁搷浣滅缉鍚堝墏鐨勬爣鍑嗘楠わ紝鍏舵牳蹇冨唴瀹逛竴鏂归潰鏄┛鐫€瀹為獙闃叉姢鏈嶏紝浣╂埓鎵嬪銆佸彛缃┿€佹姢鐩暅绛夊繀瑕侀槻鎶よ澶囷紱鍙︿竴鏂归潰鍒欐槸鍦ㄩ€氶姗卞唴绉伴噺鍜屾搷浣溿€傚湪宸ヤ笟鐣岋紝瑙勮寖鐨勪紒涓氫細鏈変笓闂ㄧ殑瀹為獙瀹ゅ拰鎿嶄綔瑙勮寖鏉ヤ繚闅滄搷浣滆€呬娇鐢ㄩ珮鐢熺墿娲绘€х墿鏂欐椂鐨勫畨鍏ㄣ€傚湪鍥藉唴楂樻牎涓櫎浜嗘墜濂楃鍐呮搷浣滀互澶栵紝閫氶姗辩О閲忓父瑙勭缉鍚堝墏杩欑鎿嶄綔杩樻槸灏戣鐨勩€傚ぇ瀹跺線寰€绉伴噺闈炵┖姘旀晱鎰熻瘯鍓傛椂浼间箮閮藉湪鏅€氣€滃ぉ骞冲鈥濆畬鎴愩€?/p>

涓嶇煡閬撳悇浣嶆湁娌℃湁鎬濊€冭繃鑷繁鎴栧疄楠屽鎴愬憳鏄惁瀵规煇浜涜瘯鍓傝繃鏁忓憿锛?/p>

鍙傝€冭祫鏂欙細

1. Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU. J. Org. Chem., 2020, 85, 1764鈥?768, DOI: 10.1021/acs.joc.9b03280

https://pubs.acs.org/doi/abs/10.1021/acs.joc.9b03280

2. What Is an Allergy Sensitizer, and How Does a Chemical Become One? ACS Chem. Health Saf., 2020, 27, 75鈥?7, DOI: 10.1021/acs.chas.0c00025

https://pubs.acs.org/doi/10.1021/acs.chas.0c00025

3. Nowick research group

https://www.chem.uci.edu/~jsnowick/groupweb/

锛堟湰鏂囩敱涔愬彧鍚涘瓙渚涚锛?/p>

浣犲鍖栧璇曞墏杩囨晱鍚楋紵,浣犲鍖栧璇曞墏杩囨晱鍚楄嫳璇?/strong>