姘ㄥ熀閰镐唬璋㈢殑姒傝堪
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鈼?鏈熷垔锛欽ournal of Proteomics
鈼?鍙戣〃鏃堕棿锛?020-05
鐮旂┒鑳屾櫙
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鐮旂┒璺嚎
浣滆€呭熀浜嶧BGM(fast blood glucose monitoring) 灏嗗叆缁勭殑T2DM妯″瀷涓崕浠撻紶鎸夋牴鎹瓼BG鍒嗕负control缁勪笌diabetes缁勶紙control, n=4; diabetes, n=4锛夛紝鍙婇€氳繃OGTT锛坥ral glucose tolerance test锛夌‘淇濋€夊彇鐨勪腑鍗庝粨榧犵鍚堝悗缁殑妫€娴嬪疄楠岋紱鍙栧叆缁勪腑鍗庝粨榧犵殑灏忚偁缁勭粐鍙婂搴旂殑琛€娓呮牱鏈紝鍒嗗埆鍋氬熀浜嶭C-MS/MS铔嬬櫧璐ㄧ粍瀛﹀拰GC-MS/MS浠ｈ阿缁勫妫€娴嬶紝瀵硅幏鍙栧埌鐨勫樊寮傝泲鐧借川涓庡樊寮備唬璋㈢墿杩涜鐢熶俊瀛﹁仈鍚堝垎鏋愶紝骞跺鍏朵腑鐨勫叧閿泲鐧絎B楠岃瘉锛屼粠鑰屽緱鍒颁腑鍗庝粨榧燭2DM妯″瀷浠ｈ阿绱婁贡鐨勭浉鍏虫満鍒躲€?/p>
鐮旂┒缁撴灉
1.T2DM涓崕浠撻紶鐨勮〃鍨嬬壒鐐?/strong>
涓浗浠撻紶鏄疶2DM鐨勮嚜鍙戞ā鍨嬶紝浠庝笁涓湀澶х殑琛€绯栧彉鍖栧紑濮嬶紝鍦?2涓湀澶ф椂寮€濮嬫偅涓婄硸灏跨梾 銆傛瘮杈僤iabetic 浠撻紶鍜宯on-diabetic 瀵圭収缁勶紝FBG缁撴灉鏄剧ず锛宒iabetic浠撻紶FBG姘村钩楂樹簬瀵圭収缁勶紝OGTT缁撴灉鏄剧ず锛屽湪30min鏃讹紝diabetic浠撻紶绯栬€愰噺鏄庢樉鍙楁崯銆?/p>
2.Diabetic浠撻紶灏忚偁缁勭粐鏍锋湰宸紓铔嬬櫧璐ㄩ壌瀹氫笌鍔熻兘瀵岄泦鍒嗘瀽
鏈€缁堟娴嬪埌231绉嶅樊寮傝泲鐧斤紝鍏朵腑117绉嶈泲鐧借〃杈句笂璋冿紝96绉嶈泲鐧借川琛ㄨ揪涓嬭皟锛涜繖浜涘樊寮傝泲鐧借川涓昏涓庣硸鑴備笌姘ㄥ熀閰镐唬璋紝鑳板矝绱犲垎娉屽強鑳板矝绱犳姷鎶楁湁鍏炽€侭iological Process鍒嗙被鍙戠幇锛宒iabetic浠撻紶鏈夊绉峛iological processes鍑虹幇寮傚父锛屼緥濡傝灏忔澘娲诲寲锛屼箼閱囩敓鐗╁悎鎴愬拰鍑濊锛汳olecular Function鍒嗙被鍙戠幇锛屽ぇ澶氭暟宸紓铔嬬櫧涓庨叾娲绘€ф湁鍏筹紱KEGG淇″彿閫氳矾鍒嗘瀽鍙戠幇锛屽ぇ澶氭暟鏄捐憲宸紓鐨勪俊鍙烽€氳矾涓庝簹楹绘补閰革紝鐢樻皑閰革紝涓濇皑閰稿強鑻忔皑閰镐唬璋紝绯栬剛涓庤泲鐧借川娑堝寲鍚告敹鏈夊叧銆備粠鑰岃鏄巇iabetic浠撻紶澶氱浠ｈ阿閫氳矾鍙戠敓浜嗗紓甯搞€?/p>
3.瀵逛袱缁勪粨榧犵殑琛€娓呮牱鏈繘琛屼唬璋㈢粍瀛﹀垎鏋?/strong>
鍦ㄦ€诲叡閴村畾鍒扮殑251绉嶄唬璋㈢墿涓紝14绉嶆湁鏄庢樉宸紓锛屽寘鎷?0绉嶆皑鍩洪吀锛?绉嶈剛鑲吀鍜?绉嶆湁鏈洪吀锛屽叾涓櫎浜?-缇熷熀鑻敳閰革紝鍏朵綑13绉嶉兘鐩歌緝浜庡鐓х粍娴撳害涓婂崌銆傚湪diabetic浠撻紶涓互涓嬩唬璋㈤€斿緞鍙戠敓浜嗘樉鐫€鍙樺寲锛氳胺鑳辩敇鑲戒唬璋紝鑻笝姘ㄩ吀锛岄叒姘ㄩ吀鍜岃壊姘ㄩ吀鐨勭敓鐗╁悎鎴愶紝绮炬皑閰稿拰鑴皑閰镐唬璋€傝繖浜涚粨鏋滆鏄庯紝diabetic浠撻紶涓昏鏄皑鍩洪吀浠ｈ阿鍙戠敓浜嗘槑鏄惧紓甯搞€?/p>
4.浠ｈ阿缁勫涓庤泲鐧借川缁勫鑱斿悎鍒嗘瀽
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5.瀵逛腑鍗庝粨榧犲皬鑲犵粍缁囦腑鍏抽敭铔嬬櫧涓板害楠岃瘉
WB缁撴灉鏄剧ず锛屼笌瀵圭収缁勭浉姣旓紝PGAM1, PHGDH, GATM, CTH涓嶤BS鐨勮〃杈惧惈閲忔槑鏄句笂璋冿紝杩欎笌LC-MS/MS鐨勭粨鏋滀竴鑷淬€?/p>
鐮旂┒缁撹
浣滆€呴€氳繃瀵瑰皬鑲犺繘琛岃泲鐧借川缁勫鍒嗘瀽锛岀粨鍚堜粨榧犺娓呯殑浠ｈ阿缁勫鍒嗘瀽瀵逛腑鍗庝粨榧犱綔涓篢2DM妯″瀷鐨勫彲琛屾€ц繘琛屼簡楠岃瘉銆備綔鑰呬粠鍒嗗瓙瑙掑害瀵硅妯″瀷鐨勭壒寰佽繘琛屼簡璇勪环銆傛澶栵紝浣滆€呭彂鐜板湪T2DM鐨勫彂鐢熷拰鍙戝睍杩囩▼涓紝璇ユā鍨嬬殑浠ｈ阿寮傚父鐜拌薄灏ゅ叾绐佸嚭锛屽挨鍏舵槸姘ㄥ熀閰哥殑浠ｈ阿銆傝繖浜涘彂鐜颁笉浠呮彁渚涘熀鏈暟鎹互鏀寔涓崕浠撻紶T2DM妯″瀷鐨勫箍娉涘簲鐢紝涔熶负鎺㈢储T2DM鐩稿叧鐨勬満鍒舵彁渚涗簡鏂扮殑瑙嗚銆?/p>
鍔╁姏绉戠爺
杩堢淮浠ｈ阿
杩堢淮浠ｈ阿
姝︽眽杩堢壒缁村皵鐢熺墿绉戞妧鏈夐檺鍏徃锛堢畝绉扳€滆繄缁翠唬璋⑩€濓級浣嶄簬姝︽眽鍥藉鐢熺墿浜т笟鍩哄湴–鍏夎胺鐢熺墿鍩庯紝涓撴敞浜庢彁渚涢鍏堢殑浠ｈ阿缁勫鎶€鏈紑鍙戝強鏈嶅姟銆傝繄缁翠唬璋㈠垱鏂颁簡鈥滃箍娉涢澏鍚戜唬璋㈢粍鈥濇妧鏈紝鍩轰簬鈥滀唬璋㈢粍+鍩哄洜缁?杞綍缁勨€濆缁勫鐮旂┒鏂规锛岃繎骞存潵浠ラ€氳浣滆€呰韩***Cell銆丯ature Communications 銆丯ature Genetics 銆丳NAS绛夊浗闄呭鏈湡鍒婂彂琛ㄥ绡囪鏂囷紝寮曢鍩哄洜缁勬椂浠ｇ殑浠ｈ阿鐢熺墿瀛︾爺绌舵柊鏂瑰悜銆?/p>
灏忚偁铔嬬櫧璐ㄧ粍瀛﹁仈鍚堣娓呬唬璋㈢粍瀛︽彮绀篢2DM涓崕浠撻紶姘ㄥ熀閰镐唬璋㈢磰涔?/strong>
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