姘ㄥ熀閰?鍐?/strong>
鐧岀棁鍐风煡璇嗭綔鐧岀粏鑳炩€滅埍鍚冣€濇竻鍗曪紙浜岋級锛氭皑鍩洪吀涓庣檶鐥囩殑鎭╂仼鎬ㄦ€?/strong>
寮曡█锛氫粖澶╋紝鏋佸吇鍚涚户缁笌澶у娣卞害鍓栨瀽銆岀檶缁嗚優鐨勨€滅埍鍚冣€濇竻鍗曘€嶏紝涓婁竴鏈熻皥鍒颁簡鐧岀粏鑳炰笉鍗曞崟鍙€滅埍鍚冣€濈硸锛屾帴涓嬫潵鎴戜滑涓€璧疯皥涓€涓嬬檶缁嗚優涓庢皑鍩洪吀鐨勬仼鎬ㄣ€?/p>
鐧岀粏鑳炵埍鈥滃悆鈥滄皑鍩洪吀
鐧岀粏鑳炴槸鐢辨甯哥粏鑳炶浆鍙樿€屾潵锛屾甯哥粏鑳為渶瑕佺殑钀ュ吇鐗╄川锛屽畠浠悓鏍烽渶瑕侊紝鍙槸姣斾緥涓婁細鏈夋墍宸紓銆傞櫎浜嗚憽钀勭硸鍜屼钩閰镐互澶栵紝鐧岀粏鑳炰篃鍚屾牱闇€瑕佹皑鍩洪吀鏉ュ悎鎴愯泲鐧借川锛岃€屼笖涓轰簡婊¤冻鍏剁壒娈婄殑鐢熼暱闇€姹傦紙蹇€熺箒娈栨墿鏁ｏ級锛屽畠浠線寰€浼氬鏌愪簺姘ㄥ熀閰哥殑闇€姹傚ぇ澶у鍔犮€傚洜姝わ紝姘ㄥ熀閰稿湪寰堝鐧岀粏鑳炵殑鐢熼暱銆佷俊鍙蜂紶瀵兼垨鏄哀鍖栦腑鍏呭綋閲嶈鐨勫獟浠媅1]銆傝繎浜涘勾鏉ワ紝寰堝鐮旂┒鍙戠幇閫氳繃鎺у埗鏌愪簺姘ㄥ熀閰哥殑鎽勫叆銆佺敓鐗╁悎鎴愭垨鏄繍杈撳彲浠ユ姂鍒剁檶缁嗚優鐨勫娈栧拰鎵╂暎銆傜瀛﹀浠凡缁忓湪瀹為獙涓瘉瀹炰簡锛?/span>
璋锋皑閰拌兒涓庤偤鐧?Gln
鎶戝埗璋锋皑閰拌兒杞繍铔嬬櫧鍙互鎶戝埗鑲虹檶缁嗚優鐨勭敓闀垮拰澧炴畺锛屽鍔犵檶缁嗚優鐨勬哀鍖栧簲婵€鍙嶅簲锛屽姞閫熻偤鐧岀粏鑳炵殑姝讳骸[2]銆?/span>
涓濇皑閰?鐢樻皑閰镐笌娣嬪反鐧屽拰鑲犵檶 Ser/Gly
鍑忓皯涓濇皑閰稿拰鐢樻皑閰哥殑鎽勫叆鍙互浣垮皬榧犱綋鍐呮穻宸寸檶缁嗚優鍜岃偁鐧岀粏鑳炲鏌愪簺鍖栧鐗╄川鏇存晱鎰燂紝鍥犺€屼綆涓濇皑閰搞€佺敇姘ㄩ吀椋熻氨鍙互閰嶅悎鍖栫枟鍜屾斁鐤椾娇鐢紝鍔犲己鍖栫枟鍜屾斁鐤楃殑鏁堟灉[3]銆?/span>
绮炬皑閰镐笌楠ㄨ倝鐦?Arg
绮炬皑閰告槸寰堝鐧岀粏鑳炵敓闀垮繀涓嶅彲灏戠殑鐗╄川涔嬩竴銆傜劧鑰屾煇浜涚檶缁嗚優锛屼緥濡傞鑲夌槫缁嗚優锛屽叾涓簿姘ㄧ惀鐝€閰稿悎鎴愰叾鐨勮〃杈捐緝浣庯紝瀵艰嚧鐧岀粏鑳炰腑绮炬皑閰告按骞宠緝浣庯紝鏈€缁堝鍔犱簡楠ㄨ倝鐦ゅ悜鑲洪儴杞Щ鐨勬鐜嘯4]銆?/span>
澶╁啲閰拌兒涓庝笁闃翠钩鑵虹檶 Asn
鍑忓皯椋熺墿涓殑Asn鐨勬憚鍏ワ紝鍙互鏈夋晥鎶戝埗鎮ｆ湁涓夐槾鎬т钩鑵虹檶锛圱riple-negative Breast Cancer锛孴NBC锛夌殑灏忛紶鐨勭檶鐥囩殑鎵╂暎锛屼粠鑰岄檷浣庝钩鑵虹檶鐨勮嚧姝荤巼[5]銆?/span>
铔嬫皑閰镐笌缁撶洿鑲犵檶鍜岃蒋缁勭粐鑲夌槫 Met
2019骞?鏈?鏃ワ紝鍒氬垰鍙戣〃浜庛€奛ature銆嬩笂鐨勬渶鏂扮爺绌跺彂鐜帮紝闄愬埗绾㈣倝鍜岄浮铔嬩腑鐨勮泲姘ㄩ吀鎽勫叆锛屽彲鏄捐憲澧炲己灏忛紶鐨勭檶鐥囩枟鏁堬紝鎶戝埗鑲跨槫鐢熼暱[6]銆?/span>
闈炲繀闇€姘ㄥ熀閰镐笌涔宠吅鐧岀粏鑳濭ln锛孲er锛孏ly锛孋ys锛堝崐鑳辨皑閰革級
涔宠吅鐧岀粏鑳炵殑鐢熼暱鍜岃浆绉讳笌璁稿闈炲繀闇€姘ㄥ熀閰革紙濡侴ln锛孲er锛孏ly锛孋ys锛夌殑浠ｈ阿涔熷瓨鍦ㄧ潃鍗冧笣涓囩紩鐨勮仈绯伙紝渚嬪[1]锛?/span>
- 鎶戝埗璋锋皑閰拌兒閰剁殑娲绘€у彲浠ュ厠鍒舵棤闆屾縺绱犲彈浣擄紙ER锛夌殑涔宠吅鐧岀殑鍙戝睍锛?/span>
- 鍑忓皯涓濇皑閰稿拰鐢樻皑閰哥殑鎽勫叆浼氶檷浣庝钩鑵虹檶缁嗚優鐨勫娈栭€熺巼锛?/span>
- 鍗婅儽姘ㄩ吀鍦ㄤ钩鑵虹檶缁嗚優閲岀殑娴撳害姣斿湪姝ｅ父缁嗚優楂樺嚭13%锛岃瘉鏄庡崐鑳辨皑閰稿彲浠ヤ綔涓轰钩鑵虹檶缁嗚優鐨勫彂灞曟爣璇嗙墿銆?/span>
杩欎簺鐮旂┒鍐嶆鍛婅瘔鎴戜滑锛岀檶缁嗚優涓轰簡鐢熷瓨锛屽彲浠ュ姩鐢ㄨ澶氳繚鑳屾垜浠父瑙勬€濈淮鐨勨€滄鍣ㄢ€濓紝璁稿鐪嬩技鍙湁鍙棤鐨勬皑鍩洪吀鍒颁簡鐧岀粏鑳炶繖閲岋紝灏卞彉鎴愪簡鈥滄潃浜哄埄鍣ㄢ€濓紝鍥犳锛屾垜浠繀椤昏鑳藉鍏ㄦ柟浣嶅湴璁よ瘑杩欎釜鏁屼汉锛屽洜涓哄畠鐪熺殑鏄€滈亾楂樹竴灏猴紝榄旈珮涓€涓堚€濓紒锛侊紒
鐧岀粏鑳炵埍纰虫按銆佺埍姘ㄥ熀閰革紝
鏄笉鏄寰楀皯浜嗗暐锛?/span>
瀵癸紒
閭ｅ氨鏄剛鑲吀锛?/span>
渚濈収鐧岀粏鑳炵殑鏅哄晢锛?/span>
浣犺寰楀畠浼氬繕璁拌剛鑲吀锛堣剛绫伙級杩欎釜鈥滄鍣ㄢ€濆悧锛?/span>
绛旀褰撶劧鏄?/span>
NO!!!!
>>> 棰勫憡锛氫笅涓€鏈燂紝鏋佸吇鍚涗細缁х画涓哄ぇ瀹跺墫鏋愩€婄檶缁嗚優鈥滅埍鍚冣€濇竻鍗曪紙涓夛級锛氱檶缁嗚優鏃犳硶鎷掔粷鑴傜被鐨勮鎯戯紵銆?/strong>
>>> 鏁鏈熷緟 [寰楁剰]
鎾板啓锝淗aoran PHD 缂栧锝淴inyin PHD, RD
缂栬緫锝淢andy Wu 璁捐锝淔ay
澹版槑锛氭湰鏂囩敱銆婃瀬鍏昏鐣屻€嬶紙JiYang_Vision锛夐娆″彂甯冿紝濡傞渶杞浇闇€浜嬪厛鍙栧緱鏈钩鍙颁功闈㈡巿鏉冿紝骞跺繀椤绘爣鏄庢枃绔犺浆杞藉嚭澶勶紱鏂囩珷鐗堟潈褰掋€婃瀬鍏昏鐣屻€嬫墍鏈夛紝鏈粡鎺堟潈锛屼换浣曚釜浜?鏈烘瀯涓嶅緱鎿呰嚜鍒婄櫥鎴栧湪鍏朵粬濯掍綋涓婅浆杞藉叏閮ㄦ垨閮ㄥ垎鏂囩珷鍐呭銆?/strong>
Reference
[1] Geck RC, Toker A. Nonessential amino acid metabolism in breast cancer. Adv Biol Regul. 2016 Sep;62:11-17. doi: 10.1016/j.jbior.2016.01.001. Epub 2016 Jan 21. Review.
[2] Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat Med. 2018 Feb;24(2):194-202. doi: 10.1038/nm.4464. Epub 2018 Jan 15.
[3] Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH. Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature. 2017 Apr 19;544(7650):372-376. doi: 10.1038/nature22056. Erratum in: Nature. 2017 Aug 2;548(7665):122.
[4] Kobayashi E, Masuda M, Nakayama R, Ichikawa H, Satow R, Shitashige M, Honda K, Yamaguchi U, Shoji A, Tochigi N, Morioka H, Toyama Y, Hirohashi S, Kawai A, Yamada T. Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. Mol Cancer Ther. 2010 Mar;9(3):535-44. doi: 10.1158/1535-7163.MCT-09-0774. Epub 2010 Feb 16.
[5] Mauro-Lizcano M, L贸pez-Rivas A. Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells. Cell Death Dis. 2018 Feb 12;9(2):205. doi: 10.1038/s41419-018-0263-0.
[6] Dietary methionine influences therapy in mouse cancer models and alters human metabolism. Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP Jr, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G, Kirsch DG, Hsu DS, Nichenametla SN, Locasale JW. Nature. 2019 Jul 31. doi: 10.1038/s41586-019-1437-3. [Epub ahead of print]
鐧岀棁鍐风煡璇嗭綔鐧岀粏鑳炩€滅埍鍚冣€濇竻鍗曪紙浜岋級锛氭皑鍩洪吀涓庣檶鐥囩殑鎭╂仼鎬ㄦ€?/strong>
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